2型糖尿病患者血清hs-CRP、FIB检测的临床价值

Clinical Value of Detection of Serum hs-CRP,FIB in Type 2 Diabetes Mellitus Patients

目的研究超敏C-反应蛋白(hs-CRP)和纤维蛋白原(FIB)预测2型糖尿病并发动脉粥样硬化的临床价值。方法对50例2型糖尿病患者和30例健康体检者同时检测hs-CRP、FIB。采用乳胶增强透射比浊法测定hs-CRP,用Clauss方法检测FIB。结果2型糖尿病患者的hs-CRP、FIB均明显升高,与正常对照组比较有显著性差异(P<0.01)。结论hs-CRP、FIB作为急性时相反应蛋白,在预测和监视2型糖尿病并发动脉粥样硬化方面有重要的临床价值,联合测定为2型糖尿病患者并发症的早期预防、诊断、治疗及预后评价手段提供了理论依据。

Objective Discovering clinical value of ultra high-sensitivity C-response protein（hs-CRP）and fibrinogen（FIB）to forecast type 2 diabetes mellitus（T2DM）concurrent atherosclerosis.Methods Detecting hs-CRP and FIB in fifty T2DM patients and thirty healthy people simultaneously by using the emulsion enhancement transmission turbidimetric method and the Clauss method.Results Both hs-CRP and FIB level are obviously elevated in T2DM patients with atherosclerosis comparing to normal controls.There is a significant difference between two groups（P〈0.01）.Conclusion hs-CRP and FIB are fast response proteins and are valuable to forecasting and monitoring T2DM with atherosclerosis;The conciudion also provide the theory basis for early prevention,diagnosis,treatment and prognosis in T2DM with complication.