盐酸曲马多的毒性不容低估
摘要
盐酸曲马多（tramadol hydrochlorid，曲马多）为阿片类中枢性镇痛剂。它包括两个对映体，其中（＋）对映体及其O^-去甲基（＋）代谢物是μ阿片受体拮抗剂，并可刺激血清素释放和抑制其再摄取，而（-）对映体则抑制神经元触突对去甲肾上腺素的再摄取和增加神经元外5-羟色胺浓度，从而发挥对疼痛传导的抑制作用。两种对映体的互补和协同作用可改善止痛效果和耐受性。也有人认为，
出处
《中华风湿病学杂志》
CAS
CSCD
2008年第2期73-74,共2页
Chinese Journal of Rheumatology
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