二杈狗牙花中生物碱的研究

Studies on the Alkaloids of Erchagouyahua (Ervatamia divaricata)

从西双版纳采集的二杈狗牙花Ervatamiadivaricata中分得8个生物碱。经理化分析和光谱测定鉴定为：coronaridine（Ⅰ），voacangine（Ⅱ），tabernaemontanine（Ⅲ），dregamine（Ⅳ），20－epiervatamine（Ⅴ），tabernaelegantineA（Ⅵ），狗牙花J－A（ervadivaricatineA，Ⅶ）和狗牙花J－B（ervadivaricatineB，Ⅷ）。其中Ⅶ和Ⅷ为新化合物。Ⅶ对P－388肿瘤细胞有明显的抑制作用。

Eight indole alkaloids have been isolated from Ervatamia divaricata(L. )Burk. According to the chemical and spectroscoplo data,they were identified as coronaridine(Ⅰ),voacangine(Ⅱ),tabernaemontanine(Ⅲ),dregamine (Ⅳ), 20-epi-ervatamine (Ⅴ) , tabernaelegantine A (Ⅵ ), ervadivaricatine A (Ⅶ). ervadivaricatine B (Ⅷ). Ⅶ and Ⅷ are new and Ⅶ shows singnificant inhibitory activity against P-388 tumor in vivo at dosage of 12~21 μg/kg level.