槲皮素二硫酸酯二钠对猪血小板F-肌动蛋白生成的影响

Effect of Disodium Quercetin Disulfate on the Formation of F-actin in Pig Platelet Induced by Thrombin

槲皮素二硫酸酯二钠是以槲皮素为原料合成的一种水溶性黄酮类化合物。采用曲拉通（Triton）沉淀法研究槲皮素二硫酸酯二钠与肌动蛋白微丝（F-肌动蛋白）生成间的关系，结果表明槲皮素二硫酸酯二钠可强烈抑制凝血酶诱导的猪血小板肌动蛋白的聚合，半数抑制率（IC50）=30μmol／L。结果提示槲皮素二硫酸酯二钠具有较强的抗血小板作用。

Disodium quercetin disulfate is a water soluble quercetin derivative. By studying the relation between disodium quercetin disulfate and F-actin fortnation in pig platelets,it has been found that the derivative can strongly inhibit actin polymerization induced by thrombin with an IC50 = 10 μmol/L,suggesting that disodium quercetin disulfate is a rather potent antiplatelet agent.