丁咯地尔与肌氨肽苷联合治疗糖尿病周围神经病疗效观察

Observation Of Curative Effect Of Buflomedil Injection And Muscular Amino Acids And Peptides And Nucleosides Injection For Treating Diabetic Peripheral Neuropathy

目的:观察丁咯地尔与肌氨肽苷联合治疗糖尿病周围神经病变的疗效。方法:86例患者随机分为治疗组和对照组各43例。治疗组:在常规治疗基础上应用丁咯地尔150mg加入生理盐水250ml、肌氨肽苷8ml加入生理盐水250ml中静脉滴注,每日一次;对照组:在常规治疗基础上维生素B1100mg、维生素B12500μg肌肉注射,每日一次。连续治疗4周。结果:治疗组:显效29例,有效9例,无效5例;总有效率88.3%,明显高于对照组的62.8%,经秩和检验P<0.01,且未见明显副作用。结论:丁咯地尔与肌氨肽苷联合治疗糖尿病周围神经病变是较理想的药物。

Objective： To observe the effect of buflomedil injection and muscular amino acids and peptides and nucleosides injection to treat diabetic peripheral neuropathy. Methods：86 patients with diabetic peripheral neuropathy were divided randomly into two groups. 43 cases in the treated group were treated with routine treatment ＋ buflomedil injection ＋ Muscular amino acids and peptides and nucleosides injection; 43 cases in the control group were treated with routine treatment ＋ vitamin B1 ＋ vitamin B12. Results： The effective rate of treated group was 88.3 %, higher than that of the control group（62.8% ） （P〈0.01）. There was no obvious side effect. Conclusion： Buflomedil injection and Muscular amino acids and peptides and nucleosides injection are effective medicine for treating diabetic peripheral neuropathy.