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重新认识视神经脊髓炎 被引量:7

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摘要 视神经脊髓炎(neuromyelitis optica,NMO),又称Devic病,是视神经和脊髓同时或相继受累的急性或亚急性脱髓鞘病变,与多发性硬化(multiple sclerosis,MS)同属中枢神经系统(CNS)脱髓鞘疾病。NMO是MS的一种亚型还是一个独立的疾病尚存在争议。由于治疗上的特殊性,明确NMO与MS两者的概念十分必要。Lennon等于2004年发现了NMO的特异性的标记物NMO—lgG,引发了人们对NMO的重新思考。本文就近几年来NMO和MS发病机制、诊断和治疗等方面的研究概况,谈谈我们的认识,以引起大家的重视。
出处 《中华神经科杂志》 CAS CSCD 北大核心 2008年第2期76-78,共3页 Chinese Journal of Neurology
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参考文献16

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二级参考文献20

  • 1Lennon VA,Wingerchuk DM,Kryzer TJ,et al.A serum autoantibody marker of neuromyelitis optica:distinction from multiple sclerosis.Lancet,2004,364:2106-2112.
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  • 3Bergamaschi R,Tonietti S,Franciotta D,et al.Oligoclonal bands in Devic's neuromyelitis optica and multiple sclerosis:differences in repeated cerebrospinal fluid examinations.Mult Scler,2004,10:2-4.
  • 4Zaffaroni M; Italia Devic's Study Group.Cerebrospinal fluid findings in Devic's neuromyelitis optica.Neurol Sci,2004,25Suppl 4:S368-S370.
  • 5Milano E,DiSapio A,Malucchi S,et al.Neuromyelitis optica:importance of cerebrospinal fluid examination during relapse.Neurol Sci,2003,24:130-133.
  • 6Lennon VA,Wingerchuk DM,Kryzer TJ,et al.A serum autoantibody marker of neuromyelitis optica:distinction from multiple sclerosis.Lancet,2004,364:2106-2112.
  • 7Kikuchi S,Fukazawa T."OSMS is NMO,but not MS":confirmed by NMO-IgG? Lancet Neurol,2005,4:594-595.
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  • 10Diem R,Hobom M,Marier K,et al.Methylprednisolone increases neuronal apoptosis during autoimmune CNS inflammation by inhibition of an endogenous neurroprotective pathway.J Neurosci,2003,23:6993-7000.

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