摘要
目的:观察电针“夹脊”穴对大鼠鞘内注射P物质(SP,10μg)引起的痛反应和脊髓c-fos原癌基因蛋白表达的影响。方法:采用免疫组织化学法和痛阈测定法。结果:大鼠鞘内注射SP可引起痛反应,并诱发脊髓c-fos样免疫反应(FLI)减少,此效应可部分被纳洛酮(Nx)翻转。结论:电针可能是通过内源性阿片肽抑制SP而产生镇痛作用。
Objective: To observe the effects of electroacupuncture at the 'Jiaji' point on pain response and c fos expression in spinal cord induced by intrathecal injection of substance P (SP, 10 μg) in rats. Methods: Immunohistochemistry and measurement of pain were used. Results: The intrathecal injection of SP produced pain response and evoked c fos expression in spinal cord. 1 h after the injection of SP, the FLI neurons were localized in laminae I, II, V and VI of both sides of the spinal cord. Electroacupuncture at the 'Jiaji' point could inhibit pain response and c fos expression, which could be partially reversed by naloxone. Conclusion: Electroacupuncture might exert its analgesic effects through stimulating the internal opiate peptide to inhibit SP.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1997年第4期332-335,共4页
Journal of Third Military Medical University