大鼠实验性胃癌发生中前列腺素E_2、F_(2α)的作用探讨

Role of prostaglandins E 2 and F 2α in the oncogenesis of gastric carcinoma induced with N methyl N' nitro N nitrosoguanidine in rats

目的：观察前列腺素在实验性胃癌发生中的作用。方法：用放射免疫技术测定大鼠血浆和胃粘膜组织中前列腺素Ｅ２、前列腺素Ｆ２α含量。结果：①前列腺素Ｅ２含量：癌组织非常显著地大于异型增生、肠上皮化生及正常胃粘膜组织（Ｐ＜０．０１）；异型增生和肠上皮化生组织显著高于正常胃粘膜组织（Ｐ＜０．０５）。②前列腺素Ｆ２α含量：癌组织显著大于异型增生、肠上皮化生与正常胃粘膜组织（Ｐ＜０．０５）；后三者之间无显著差异（Ｐ＞０．０５）。③血浆前列腺素Ｅ２、前列腺素Ｆ２α含量：发癌鼠显著大于癌前病变鼠和正常鼠（Ｐ＜０．０５）。结论：前列腺素Ｅ２、前列腺素Ｆ２α在实验性胃癌发生中可能具有一定作用。

Objective: To investigate the role of prostaglandins in occurrence of gastric carcinoma(GC). Methods: After the mode of GC was established by induction of N methyl N' nitro N nitrosoguanidine (MNNG) in 60 Wistar rats, the contents of prostaglandins E 2 and E 2α (PGE 2,PGE 2α ) in plasma and gastric mucosa were measured with radioimmunoassay. Results: 1) the content of PGE 2 was significantly higher in the tissue of GC than in those of dysplasia, intestinal metapiasia (lM) and normal gastric mucosa (NGM) (P<0.01) and those were also remarkably higher in tissue of dysplasia and lM than in that of NGM (P< 0.05 ); 2) The content of PGE 2α was significantly higher in the tissue of GC than in those of dysplasia, lM and NGM (P<0.05) but no significant difference was found among the latter three (P>0.05); 3) The contents of PGE 2 and PGE 2α were significantly higher in the plasma of rats with GC than in normal ones and those with precancerous lesions (P<0.05). Conclusion: PGE 2 and PGE 2α play an important role in the occurrence of GC.