摘要
目的:通过辛伐他汀对不稳定型心绞痛患者血浆组织型纤溶酶原激活物t-PA与纤溶酶原激活抑制剂-1(PAI-1)的影响,来探讨其对不稳定型心绞痛患者纤溶活性的影响。方法:61例不稳定性心绞痛患者随机分为2组:常规治疗组30例,辛伐他汀治疗组31例,比较其在治疗前、后t-PA、PAI-1的活性水平的变化。结果:辛伐他汀治疗后PAI-1降低,差异有显著性;t-PA活性呈上升趋势,但无统计学意义(P>0.05);结论:辛伐他汀可明显改善不稳定型心绞痛患者血浆纤溶活性。
Objective： To explore the effect of simvastatin on tissue plasminogen activator, plasminogen activator inhibitor （PAI-1） in patients with unstable angia pectoris （UAP）. Methods：61 patients with UAP were randomly divided into simvastatin therapeutic group （n= 31） and conventional therapeutic group （n= 30）. Their t-PA, PAI-1 levels were compared respectively before and after treatment. Results.. After simvastatin treatment. PAI-1 acreased and there was significant difference, the activity of t-PA had an ascending trend, but no statistical significance. Conclusion： simvastatin can improve thrombolysis significantly in patients with UAP.
出处
《医学理论与实践》
2008年第2期133-134,共2页
The Journal of Medical Theory and Practice
