高血压病人血脂与细胞膜离子转运的关系

Relationship between plasma lipids and transmembrane ion transports in patients with essential hypertension

目的：了解在高血压病中血脂对细胞膜离子转运的影响。方法：观察５１例高血压病（ＥＨ）人及２０例正常对照者血总胆固醇（ＴＣ）、甘油三脂（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－ｃ）、低密度脂蛋白胆固醇（ＬＤＬ－ｃ）、载脂蛋白Ｂ－１００（ＡｐｏＢ－１００）及红细胞膜Ｎａ＋泵、Ｎａ＋／Ｈ＋交换、４５Ｃａ２＋内流等。结果：ＥＨ病人ＴＣ、ＴＧ、ＬＤＬ－ｃ、红细胞Ｎａ＋／Ｈ＋交换、４５Ｃａ２＋内流均增高Ｎａ＋泵活性降低。４５Ｃａ２＋内流与舒张压呈正相关（Ｐ＜０．０５）。有家族史的ＥＨ病人ＴＣ、ＬＤＬ－ｃ与细胞４５Ｃａ２＋内流呈正相关，无高血压家族史ＥＨ病人血脂与细胞离子转运无显著相关性。结论：血脂代谢异常可通过影响细胞膜脂结构，进而影响膜Ｃａ２＋转运参与有遗传史的ＥＨ病人发病机理。

Objective: To explore the relationship between plasma lipids and transmembrane ion transports in patients with essential hypertension. Methods: The levels of plasma lipids, red cell Na +pump, Na +/K + exchange and 45 Ca 2+ influx were measured in 51 patients with essential hypertension and 20 normal controls. Results: The levels of plasma cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL c) and the rate of cell Na +/K + exchange and 45 Ca 2+ influx were higher but the level of red cell Na + pump was lower in the patients than in the controls. The rate of 45 Ca 2+ influx into red cells was positively correlated to diastolic blood pressure in the patients (P<0.05). TC and LDL c were positively correlated with 45 Ca 2+ influx in the patients with a family history of essential hypertension but not in those without. Conclusion: Abnormality in lipid metabolism may play an important role in the occurrence of gene related hypertension through affecting the transmembrane Ca 2+ transport.