甲状腺微粒体抗体和甲状腺过氧化物酶抗体相关性研究

Comparison of thyroid peroxidase antibody and microsomal antibody assays in sera from patients with autoimmune thyroid disease

研究了105例自身免疫性甲状腺病（AITD）患者血清甲状腺微粒体抗体（TMAb）和甲状腺过氧化物酶抗体（TPOAb）测定值的相关性，其中TMAb和TPOAb的阳性率分别为56．2％（59／105）和73．3％（77／105），呈正相关（r＝0．55，P＜0．001）;另外，TMAb阳性血清稀释度和其对甲状腺过氧化物酶单克隆抗体（TPOmAb）结合125I－hTPO的抑制性呈显著的量效关系（r＝0．98，P＜0．001），提示制备TPO单抗和AITD患者的TPOAb存在共同的hTPO的B细胞表位，以上实验结果支持TPOAb即为TMAb的观点。

The relationship between me value of TMAb and TPOAb of 105 cases witn AITD was studied． The percentages of positive results of TMAb and TPOAb were 56.2%(59/105)and 73.3%(77/105),respectively,positive correlations were found between TMAb and TPOAb（r=0． 55，P＜O．001）． The inhibition of TPO mAb－125 I－hTPO binding by TMAb positive sera of different dilutions showed significant dose-dependent relationship(r=0.98,P＜0.001)which indicated that prepared TPOmAbs and TPOAb of patients with AITD have the common B cell epitopes on hTPO.All results obtained support the view of TPOAb identity with TMAb．