系统性红斑狼疮与感染544例临床分析

Infections in systemic lupus erythematosus:retrospective clinical analysis of 544 cases

目的:研究系统性红斑狼疮(SLE)患者发生感染的规律与特点,提高诊断与治疗水平,降低死亡率。方法:回顾分析1983—1998年544例确诊为SLE患者的感染情况及其特点,以及与C反应蛋白(CRP)的关系。结果:544例SLE患者住院865例次,其中一般感染537例次,严重感染216例次(24.9%)。严重感染部位以下呼吸道最多见,为129例次(59.7%),其次为皮肤感染29例次(13.4%)和泌尿系统感染21例次(9.7%)。结论:SLE患者住院感染率较高,严重感染以G-杆菌和G+球菌为主要致病菌,其次为念珠菌与结核菌。SLE患者出现感染症状多不典型,应密切观察并结合实验室检查进行鉴别。CRP与感染密切相关,是重要的参考指标。

Objective： To investigate the infection characteristics of systemic lupus erythematosus（SLE） patients in order to improve diagnostic and therapeutic level of infection and decrease their mortality. Methods： Five hundred and forty-four cases diagnosed as SLE during 15 years from 1983 to 1998 were retrospectively studied, and the infectious characteristics, mainly the relationship between those and C-reactive protein （CRP） investigated. Results： Among total 865 case/times in 544 SLE inpatients, 537 mild episodes and 216 severe episodes（24.9%） were found, the most common case was lower respiratory tracts infections in 129 （59.7%）, the next was skin infections in 29 （13.4%）, and urinary system infections in 21 （9.7%）. Conclusions： The infection rate of SLE inpatients was rather higher. As the clinical infection manifestation of SLE being not very typical it is necessary to carry out clinical observation and examination closely, take clinical differentiating diagnosis carefully. In the laboratory examinations CRP is an important indicator related to infections.