骨桥蛋白在结肠癌中的表达

Expression and significance of osteopontin in colon cancer tissues

目的探讨骨桥蛋白(OPN)在结肠癌组织及癌旁组织中的表达及意义。方法应用免疫组织化学法检测60例结肠癌组织及50例癌旁组织中OPN的表达。结果OPN在60例结肠癌及50例癌旁组织中表达率分别为71.7%和14.0%(P<0.05)。结肠癌组织中OPN的表达与肿瘤淋巴结转移、分化程度和浸润深度相关(P<0.05)。结论OPN在结肠癌中呈高表达,且在结肠癌的侵袭转移中起重要作用。

Objective To explore the expression of osteopontin （OPN） in colon cancer, and analyze the relationship between its expression and clinicopathologic features. Methods The expression of OPN was detected by immunohistochemistry in 60 cases of colon cancer tissues and 50 cases of tumor-adjacent tissues. Results The positive rate of OPN expression in colon cancer tissues was 71.7%,which was much higher than that in tumor-adjacent tissues （P〈0. 05）. OPN expression was related with tumor invasive depth,differentiation and degree of lymphatic vessel invasion or long distant lymph node metastases （P 〈 0. 05 ）. Conclusion OPN plays an important role in the progression of colon carcinomas and may involve in the invasion and metastasis of colon carcinomas.