摘要
从红豆杉茎皮提取紫杉醇，采用１％柠檬酸渗漉、柱色谱分离、溴加成后柱色谱分离的新工艺，可以获得比较满意的结果。
Taxol was isolated from stems of Taxus chinensis. The 1% citric acid percolate was extracted with dichloromethane to obtain total terpenoids,which was then separated by colunm chromatography to obtain fractions containing taxol and cephalomannine.This fraction was treated with bromine solution in carbon tetrachloride to form bromine addition compound with cephalomannine,which was much easier to be separated from taxol by column chromatography than usual.The purity of taxol finally obtained was 99.19% analyzed by HPLC.The recovery rate of taxol from plant material was around 70%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1997年第8期344-347,共4页
Chinese Journal of Pharmaceuticals
关键词
紫杉醇
分离
工艺
taxol,technology,isolation,bromine addition
