(1S,2R,3R)-2-[(E)-3-氧代辛-1-烯基]-3-羟基-1-甲酯基环戊烷的合成

SYNTHESIS OF (1 S,2R,3R) 2 [( E ) 3 OXOOCT 1 ENYL] 3 HYDROXY 1 METHOXYCARBONYLCYCLOPENTANE

以四氢吡喃炔丙醇和１－溴－３－氯丙烷为原料经７步反应制备合成前列腺素Ｊ２的重要中间体，７－氰基－３，４－反－环氧庚－１－烯（９），并以９闭环合成（１Ｓ，２Ｒ，３Ｒ）－２－［（Ｅ）－３氧代辛－１－烯基］－３－羟基－１－甲酯基环戊烷（１６）。

Cyano 3,4 trans epoxyhept 1 ene was synthesized from tetrahydropyranyl propargyl alcohol and 1 bromo 3 chloropropane in 7 steps.Its cyclization led to the title compound which is a key intermediate in the syntheis of prostaglandin J 2 possessing antitumor activity.