藏红花对冠心病心绞痛患者血流变学的作用

A probing into the complexition of single Chinese herbs

将３５例冠心病心绞痛患者，随机分为藏红花组２０例和肠溶阿斯匹林组１５例。藏红花每日１ｇ，热水泡饮，代茶频服，最后连渣咀碎咽下；肠溶阿斯匹林５０毫克／片口服，每日１次，每次１片，４周１个疗程。结果，２组治疗前后全血比粘度均有极显著性差异Ｐ＜０．０１，２组治疗前后血浆比粘度无显著性差异Ｐ＞０．０５，组间２个样本均数ｔ检验Ｐ＞０．０５亦无差异。表明藏红花和阿斯匹林均具有降低高切变、低切变即全血比粘度，而２药对血浆粘度无作用，故２药都可用于冠心病心绞痛血流变异常中全血比粘度增高患者，但藏红花在不良反应发生率上，明显低于阿斯匹林。

Thrity-five patients (M24, F11) with angina petoris were divided into two groups.Treatment group (M13, F7 age 65.1±8.21) was treated with Tibet safflower (Flos carthami) 1g qd×4wk.po. After being infused in hot water and taken in small doses at short intervals,at lasttaken in the fecula. Control group (M11, F4 age 63.2) was treated with entetic aluble tablats of aspirin 50mg, qd×4wk.po.as control by randomized single blined method. Results showed that after treatment the reduce of level of whole blood viscosity was fall significant difference( P <0.01) in two groups (auto-control) and reduce of level of whole blood viscosity was not signifficant difference between two groups( P >0.05).Results showed also that after treatment the reduce of level of blood plasma viscosity was not significant difference in and between two groups( P >0.05). Our results suggested that both Tibet safflower and aspirin can reduse level of ehythrocyte fragilite and hemagglutination and elevate level of erythrocyte deformability,and they are do not effect on level of blood plasma viscosity.These two medicine are usefal for angina petoris with abnormity of whole blood viscosity. The side action of Tibet safflower if lighter than that of aspirin and taste of Tibet safflower is better than that of aspirin.