贝那普利对原发性高血压患者生长素水平和内皮功能影响的临床研究

Effects of benazepril on plasma ghrelin and endothelial in patients with essential hypertension

目的研究贝那普利对原发性高血压患者血浆生长素水平和血管内皮功能的影响。方法70例原发性高血压患者分为治疗组、对照组,观察比较治疗前后血浆生长素水平(Ghrelin)、一氧化氮(NO)、内皮素-1(ET-1)及血管性假性血友病因子(vWF)变化。结果治疗后Ghrelin升高,ET-1水平、vWF水平降低,NO浓度升高,差异均有显著性。结论贝那普利降压治疗同时可以提高血浆生长素水平,改善原发性高血压病人的血管内皮功能。

[Objective] To observe the the effects of benazepril on plasma ghrehn and endothelial in patients with essential hypertension. [Methods] Subjects were divided into two group： with treatment of Benazepril and common as first group, with common treatment as the other group. Before and after the treatment, plasma Ghrelin and nitrous oxide （NO）, endothelin （ET-1）, yon willber factor （vWF） were assayed by biochemical assay. [Results] Only in Benazepril group, the plasma Ghrelin and NO increased, ET-1 and vWF decreased. [Conclusions] Benazepril can increase plasma Ghrelin and improves endothelial function in patients with essential hypertension.