40例寻常型银屑病患者血清锌和PASI评分相关性分析

ANALYSIS OF LINEAR CORRELATION BETWEEN ZN AND PASI IN 40 PATIENTS WITH PSORIASIS VULGARIS

目的:观察寻常型银屑病患者进展期、稳定期、消退期血清锌与银屑病的相互关系,进一步探明银屑病的病因和发病机制。方法:对40例银屑病患者各期行PASI评分,对银屑病患者各期和对照组用原子分光光度法检测血清锌值。结果:银屑病患者在病程中血清锌较对照组显著降低,各组间有显著性差异(P<0.01);对银屑病患者血清锌与PASI评分进行直线相关分析得:进展期R=0.641、稳定期R=0.749、消退期R=0.717,P<0.01。结论:银屑病患者血清锌较正常人显著降低;锌与PASI评分呈正比关系。

Objective： To analyse the correlation between serum zinc and psoriasis vulgaris in active stable and resolution stages. Methods： Psoriasis area and severity index （PASI）in was scored in each stage,of 40 patient with psoriasis vulgaris;serum zinc content was detected through atomic absorption spectrometer in atients and healthy people.Results： Serum zinc was obviously decreased in course of psoriasis vulgaris comparing with healthy people;there were significant differences between different groups （P〈0.01）.The correlation coefficient between psoriatic serum zinc and PASI of active,stable and resolution stages of psoriasis vulgasis was R = 0.641,0.749,0.717 respectively （P〈0.01）. Conclusion： Psoriasis vulgaris serum zinc is obviously decreased comparing with healthy people; serum zinc and PASI is in positive correlation.