高渗氯化钠/右旋糖酐对失血性休克大鼠酸碱平衡的影响

Effects of hypertonic saline/dextran on blood gas following hemorrhagic shock in rats

目的探讨不同剂量7．5％高渗氯化钠／6％右旋醣酐（HSD）对失血性休克大鼠血气指标的影响，以进一步了解其抗休克的适宜剂量。方法采用SD大鼠45％重度失血性休克模型，观察4ml/kg，6ml/kg和8ml/kg7．5％的高渗氯化钠／6％的右旋糖酐（HSD）复苏对失血性休克大鼠血pH值，二氧化碳分压（PCO2），氧分压（PO2）的影响，以2倍失血量的乳酸林格氏液（LR）做对照。结果各剂量HSD输注后血氧分压和二氧化碳分压都有不同程度的升高，显著高于LR对照组，但pH值明显低于LR组，其中以HSD8ml/kg组最低，呈现明显的酸中毒。结论虽然HSD有较好的改善血流动力学指标和部分血气指标的效果，但由于大剂量输注可致机体明显的酸中毒，因此在应用时以4～6ml/kg为宜，最大剂量不超过8ml/kg。

Objective To investigate the effects of 7.5% hypertonic saline/6% dextran（HSD） on blood gas following hemorrhagic shock in rats. Methods SD rats were used to make hemorrhagic shock model by 45% hemorrhage. Effects of 4 mL/kg, 6 mL/kg and 8 mL/kg of HSD on blood gas were observed. Twice volumes of Lactated Ringer＇s （LR） were used as control. Results Blood PO2 and PCO2 had somewhat increase after different volume of HSD infusion, they were significantly higher than in LR control group. But the pH value in different volume of HSD groups was obviously lower than in LR control group, among the three dosages of HSD, the pH value in 8 mL/ kg HSD group was the lowest and appeared serious acidosis. Conclusion Although HSD can effectively improve the hemodynamic parameters and partial blood gases for hemorrhagic shock, because of the fact that large volume of HSD can cause obvious acidosis, therefore, when HSD applied, 4-6 mL/kg is the proper dosage, not more than 8 mL/kg.