摘要
The dynamic behaviour of SonoVue microbubbles, a new generation ultrasound contrast agent, is investigated in real time with light scattering method. Highly diluted SonoVue microbubbles are injected into a diluted gel made of xanthan gum and water. The responses of individual SonoVue bubbles to driven ultrasound pulses are measured. Both linear and nonlinear bubble oscillations are observed and the results suggest that SonoVue microbubbles can generate strong nonlinear responses. By fitting the experimental data of individual bubble responses with Sarkar＇s model, the shell coating parameter of the bubbles and dilatational viscosity is estimated to be 7.0 nm-s-Pa.
The dynamic behaviour of SonoVue microbubbles, a new generation ultrasound contrast agent, is investigated in real time with light scattering method. Highly diluted SonoVue microbubbles are injected into a diluted gel made of xanthan gum and water. The responses of individual SonoVue bubbles to driven ultrasound pulses are measured. Both linear and nonlinear bubble oscillations are observed and the results suggest that SonoVue microbubbles can generate strong nonlinear responses. By fitting the experimental data of individual bubble responses with Sarkar＇s model, the shell coating parameter of the bubbles and dilatational viscosity is estimated to be 7.0 nm-s-Pa.
基金
Supported by the National Natural Science Foundations of China under Grant Nos 10434070 and 10704037, the Young Scholar Technological Innovation Projects of Jiangsu Province under Grant No BK2007569, and NIH under Grant 8R01 EB00350-2
