冷循环微波固化家猪乳腺实验研究

"Water-cooled circulation" microwave coagulation in pig breast:an experiment study

目的:探讨冷循环微波固化(microwave coagulation,MC)治疗乳腺肿瘤可行性和有效性。方法:应用ECO100冷循环微波固化仪对家猪乳腺进行微波固化,术后测定MC靶区范围大小,对靶区组织、靶区周围组织作常规病理学检查,观察术后不良反应。结果:微波固化功率、时间同固化体积呈正相关,其固化功率时间乘积同体积相关系数为0.904(P<0.000),回归方程为yhat=0.117x-2.608。MC靶区乳腺细胞呈凝固性坏死改变,MC靶区与周围组织分界明显,周围组织光镜下无改变。运用冷循环微波固化技术,不良反应轻。结论:冷循环微波固化家猪乳腺,可使其发生凝固样坏死,固化范围明确,创伤小,无严重不良反应,为MC临床运用提供理论依据和数据参考。

Objective：To study the feasibility and effectiveness of ＂water-cooled circulation＂ microwave coagulation （MC） in the treatment of breast tumor. Methods：The breast of pigs underwent coagulation with ＂water-cooled＂ microwave coagulation equipment- ECO100 type. After MC procedure,the volume of target area were calculated;routine pathological examination were done in the MC 1 esion and surrounding tissue.Adverse effects on surrounding breast tissue and skin were carefully examined during and after MC ablation. Results： Coagulation volume was postivly correlated with the power and time of MC. The correlation coefficient between MC volume and cross product of MC power with time is 0.904, regression equation is y=0.117x-2.608. Target breast cells showed coagulativenecrosis changes by HE staining after MC,no clear change were obsered in surrounding tissue by HE staining. There was not skin burn and adjacent tissue damage outside targeted tissue in the treatment of ＂water-cooled circulation＂. Conclusion： ＂Water-cooled circulation＂ microwave coagulation could make breast cell coagulative-necrosis, and the coagulation circumscription was clear.The therapy was microinvasive,and no serious adverse effect was founded. The experiment provided a basis for the clinical application of microwave.