血清γ-谷氨酰转移酶水平与冠状动脉病变严重程度的关系
摘要
目的研究血清γ-谷氨酰转移酶（CGT）水平与冠状动脉病变严重程度的关系，为冠心病防治提供理论基础。方法对156例冠心病或可疑冠心病患者通过冠状动脉造影确定冠状动脉病变严重程度，γ-谷氨酰-3羧基-4-硝基苯胺法测定血清GGT水平，根据血清GGT水平分为高GGT组和正常GGT组，同时调查其他可能的危险因素。结果高GGT组糖尿病患者比例，TC、TG水平以及冠状动脉病变严重程度评分均显著高于正常GGT组。相关分析显示，血清GGT水平与冠状动脉病变严重程度呈正相关。Logistic回归分析显示GGT对于严重冠状动脉病变0R值为1．112，P值为0．010。此外，年龄、糖尿病对于严重冠状动脉病变的OR值分别为1．048和4．357，P值分别为0．017和0．003。结论血清GGT与冠状动脉病变严重程度相关，可能为严重冠状动脉病变的独立危险因素。
出处
《中国医师进修杂志（内科版）》
2008年第2期31-33,共3页
Chinese Journal of Postgraduates of Medicine
参考文献13
-
1Lee DH, Silventoinen K, Hu G, et al. Serum gamma-glutamyhransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28 838 middle-aged then and women. Eur Heart J, 2006,27( 18 ) : 2170-2176.
-
2Ruttmann E, Brant L J, Concin H, et al. Gamma-glutamyhransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163 944 Austrian adults. Circulation,2005,112( 14):2130-2137.
-
3Meisinger C, Doring A, Schneider A, et al. Serum gamma-glulamyl-transferase is a predictor of incident corunary events in apparently healthy men from the general population. Atherosclerosis, 2006,189 ( 2 ) : 297-302.
-
4Bots ML, Salanen JT, Elwood PC, et al. Gamma-glufamyltransferase and risk of stroke:the EUROSTROKE project. J Epidemiol Community Health, 2002,56 Suppl 1 : S25-29.
-
5Paolicchi A, Emdin M, Ghliozeni E, et al. lmages in cardiovascular mediclne. Human atherosclerotic plaques contain gamma-glutamyl transpepfidase enzyme activity. Circulation, 2004,109( 11 ) : 1440.
-
6Jono S.Ikari Y,Shioi A,et al Serum osteoprolegerin levels are associated with the presence and severity of coronnary artery disease. Circulation.2002,106(10): 1192 - 1194.
-
7Karp DR,Shimooku K,Lipsky PE. Expression of gamma-glutamyl transpeptidase protects ramos B Cells from oxidation-induced cell death. J Biol Chem, 2001,276(6) : 3798-3804.
-
8Hochwald SN,Harrison LE,Rose DM,et al. Gamma-glutamyl transpeptidase mediation of tumor glutathione utilization in vivo. J Natl Cancer Iast, 1996,88(3-4) : 193-197.
-
9Panlicchi A,Minotti G,Tonarelli P,et al. Gamma-glutamyl transpeptidase-dependent iron reduction and LDL oxidation-a potential mechanism in atherosclerosls. J Investig Med, 1999,47 (3):151-160.
-
10Paolicchi A, Emdin M, Passino C,et al. Beta-lipoprotein-and LDL-associated serum gamma-glutamyltransferase in patients with coronary atherosclerosis. Atherosclerosis, 2006,186(1) :80-85.
二级参考文献5
-
1Schmidt -Lucke C, Rossig L, Fichtlscherer S,et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation,2005, 111 (22) : 2981 -2987.
-
2Vasa M, Fichtlscherer S, Aicher A, et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res,2001,89 (1) :1 -7.
-
3Eizawa T, Ikeda U, Murakami Y, et al. Decrease in circulating endothelial progenitor cells in patients with stable coronary artery disease. Heart,2004,90(6) :685 -686.
-
4Imanishi T, Hano T, Sawamura T,et al. Oxidized low- density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction. Clin Exp Pharmacol Physiol,2004,31 (7) :407 - 413.
-
5Landmesser U, Engberding N, Bahlmann FH, et al. Statin - induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase. Circulation ,2004,110 (14) : 1933 - 1939.
-
1俞娟,吕昭萍.原发性胆汁性肝硬化的诊治进展[J].云南医药,2013,34(1):64-69. 被引量：4
-
2陆宁.中药配合双环醇治疗慢性乙型肝炎57例疗效观察[J].中国基层医药,2007,14(3):426-428. 被引量：5
-
3贾建峰,鹿育萨.高血压患者并发氨基转移酶正常的非酒精性脂肪肝的心血管危险因素分析[J].中华全科医师杂志,2011,10(8):552-554.
-
4汤英.中西医结合疗法对自身免疫性肝病的效果分析[J].河南医学研究,2016,25(1):162-163.
-
5卫展扬,黄虔,熊斌.尼可地尔治疗严重冠状动脉病变患者的疗效观察[J].国际医药卫生导报,2015,21(13):1870-1872. 被引量：1
-
6刘荣欣,陈慧巧,董凤霞,朱淑敏,沈莉,耿玉兰.心脏X综合征患者血清γ-谷氨酰转肽酶水平与颈动脉内膜中层厚度的关系[J].山东医药,2015,55(29):39-40. 被引量：2
-
7许通文,余木生,翟原生.曲美他嗪治疗严重冠状动脉病变患者的疗效观察[J].岭南急诊医学杂志,2015,20(3):189-190.
-
8颜友良,魏友平,吴帆,高招波,李顺辉,张卫,万明勇.冠状动脉造影患者中肾动脉狭窄的相关研究[J].实用临床医学（江西）,2008,9(7):10-12.
-
9张晓明,王晓英.心源性猝死的死因分析及预防[J].齐齐哈尔医学院学报,2005,26(8):903-904. 被引量：1
-
10满志然.胰岛素抵抗与血清GGT的相关性研究[J].心血管病防治知识（学术版）,2013,3(1):46-48.
