旋转磁场治疗印^(60)CO辐射造血损伤小鼠生存分析的实验研究

The Survival Analysis of Mice Exposed toγIrradiation and Treated with a Rotary Magnetic Field

目的:初步探讨旋转恒定磁场治疗急性骨髓型放射病的效果。方法:BALB/C小鼠按体重随机分为磁疗组和对照组,每组再各分为4组,分别接受0Gy、6.0Gy、8.0Gy、10.0Gy^(60)COγ射线全身辐射,照后,对照组不作任何处理,磁疗组接受磁场处理30d,每天2次,每次1.5h,旋转磁场强度为0.6T,比较两组小鼠30d的存活率和存活期。结果:单纯磁场处理对正常小鼠生存状态及存活率无明显影响;10.0Gy组和8.0Gy组小鼠生存率磁疗组与对照组之间比较均无统计学差异(P>0.05);6.0Gy组生存率磁疗组和对照组之间比较有统计学差异(P<0.05),其磁疗组30d平均存活率为71.43%,平均存活期为(24.93±8.43)d,对照组30d平均存活率21.41%,平均存活期为(17.07±7.70)d。结论:旋转恒定磁场不能提高10.0Gy及8.0Gy剂量所致极重度急性骨髓型放射病小鼠的生存率,但对6.0Gy所致重度急性骨髓型放射病有明显的保护作用,从而为旋转恒定磁场应用于临床治疗重度急性骨髓型放射损伤提供了实验依据。

Objective： The main view was to study the effect of a rotary magnetic field on radiation-injured mice. Methods： Male BALB/C mice were randomly divided into a control group and a magnetic treatment group according to the body weight. Then each group was randomly divided into four groups. The mice were received total body irradiation with 0Gy, 10.0Gy, 8.0Gy and 6.0Gy ^60COγ rays. The treatment group was treated with a rotary magnetic field for one and half an hour at a time, twice a day. The intensity of the rotary magnetic field was 0.6 T. The 30-day survival rate and surviving days were observed. Results： The rotary magnetic field treatment increased the survival rate and duration of the 6.0Gy γ irradiation irradiated mice to 71.43% and 24.93 ± 8.43 days from 21.41% and 17.07±7.70d days respectively, compared with the control group. But it didn＇t increase the survival rate and duration of the mice irradiated with 10.0Gy and 8.0Gy γ irradiation. Conclusions： The rotary magnetic field treatment had an obvious protective effect against the haematopoietic injury of the mice undergo 6.0-Gy irradiation, and it offered an experimental evidence for the clinical treatment of acute radiation-injured patients with rotary magnetic field.