核因子κB与动脉粥样硬化新进展

New Progress on Nuclear Factor-κB and Atherosclerosis

动脉粥样硬化(atherosclerosis,As)是一种炎症性病变,它以血管壁上巨噬细胞源性的泡沫细胞和大量趋化因子、细胞因子和生长因子堆积为主要特征。这些因子调节着固有细胞的迁移、分化和转归,最终影响动脉粥样硬化斑块形成,其中一个关键的调节因子就是转录因子核因子-κB(NF-κB)。过去它都被一直认为是一个促进动脉粥样硬化的因子,主要是由于它调节许多与动脉粥样硬化有关促炎基因的表达。最近有文献报道说NF-κB有可能在促炎、抗炎、细胞的生存和增值方面巧妙地监护着动脉粥样硬化过程的平衡。因此,本文就NF-κB与动脉粥样硬化病变有关的启动、泡沫细胞的形成、炎症、免疫、平滑肌细胞增值、纤维帽形成、细胞凋亡关系的新进展作一综述。

Atherosclerosis is an inflammatory disease, characterized by the accumulation of macrophage-derived foam cells in the vessel wall and a lot of chemokines, cytokines and growth factors. These factors regulate migration, differentiation and prognosis of resident cells, eventually influencing plaque development,in which, one of the key regulators is the transcription factor nuclear factor-κB （NF-κB）, which had been always regarded as a proatherogenic factor for it regulated the expression of many pro-inflammatory genes related to atherosclerosis. Recently, some literature reported that NF-κB might skillfully monitor the balance of atherosclerotic process in pro-inflammation , anti-inflammation , survival and proliferation of cells. So, this paper will review new progress on the relations between NF-κB and the starting, the formation of foam cells,inflammation,immunity, the proliferation of smooth muscle cells,the formation of fibrous cap related to atherosclerosis.