雀嘴茶半数致死量及病理学的初步研究

Study on Half Lethal Dose LD50 and the Histopathology of the Lyonia ovalifolia （W.） Drude

观察了云南广泛使用的雀嘴茶对小鼠的急性毒性反应及病理变化，为雀嘴茶使用安全性提供可靠的科学依据，我们以一定浓度不同体积的提取物给小鼠灌胃给药，连续观察小鼠行为活动、毒性反应程度、及死亡情况等指标，并及时对小白鼠进行病理切片观察，以获得初步毒性、病理资料。结果显示雀嘴茶半数致死量LD50为39．9g／kg，说明市售用于保健作用的雀嘴茶有一定的毒性，病理切片也说明其对胃肠道、心、肝、脑等多个脏器都有一定的病理损伤，长期使用可能会对人体造成一定的危害，应该慎重使用，甚至是禁止使用。

To measure the half lethal dose （ LDso ） and to study the the Histopathology for the leaves of the Lyonia ovalifolia（ W. ） Drude to mice,so we can drink it safely. Totally 50 mice in half genders were randomly divided into 5 groups and each had 10 mice. Feed the mice with same concentration of the Lyonia ovalifolia（ W. ） Drude, but not sam volum and observe the toxic symptom. Then calculate the LDso of the Lyonia ovalifolia（ W. ） Drude and 95% onfident limit with probability. The times of movement of mice increase after feed with big volum. Before death the mice had toxic symptom of alow respiratory rate and so on. The LD50 of the Lyonia ovalifolia（W. ） Drude is 39.9 g/kg and its 95% confident limit was 51.68 - 30.96 g/kg. The Lyonia ovalifolia（ W. ） Drude has slight toxicity to heart, enteron, brain, liver and so on.