摘要
从西罗莫司产生菌的突变株FC904-25的发酵产物中分离获得化合物Rap-D1的晶体。对其理化性质包括UV、IR、LC-MS、NMR谱等进行分析,结果表明Rap-D1与西罗莫司为同分异构体,具有相同的平面结构。通过单晶X-衍射确定了构型,它与文献报道经化学半合成获得的28-epirapamycin同质。
Rap-D1, the isomer of sirolimus, was isolated from the culture broth of sirolimus producing strain Streptomyces hygroscopicus mutant FC904-25. The chemical structure was determined by spectral data such as UV, IR, LC-MS,NMR and X-ray single crystal diffraction. Rap-D1 was identical with 28-epirapamycin.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2008年第2期80-83,共4页
Chinese Journal of Antibiotics
基金
福建省自然科学基金计划资助项目(编号:U0650004)