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桦木酸对H22荷瘤小鼠肿瘤细胞凋亡及细胞周期的影响 被引量：1

Influences of Betulinic Acid on the Cell Cycle and Cell Apoptosis on Mice of Bearing H22 Tumor Cells
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摘要 研究桦木酸对H22荷瘤小鼠生命延长率、肿瘤细胞凋亡及细胞周期的影响。结果表明桦木酸能够明显延长H22荷瘤小鼠生生存时间，其中低、中剂量效果显著（P〈0．05）；利用DNA结合性荧光探针直接对细胞DNA染色后FCM分析，桦木酸可能是通过影响H22肿瘤细胞S期而诱导肿瘤细胞凋亡。 This paper studied the influences of betulinic acid on life time prolonging effects and cell cycle and apoptosis on mice of bearing H22 tumor cells. The results showed that betulinic acid could increase the life time of H22 mice and betulinic acid could induce tumor cell apoptosis through restraining G0/G1 of S180 and blocking S of H22 by analyzing the signal using FCM after combining fluorescence probe to dye DNA.
作者 张秀娟 李秋实 凌莉莉 季宇彬 方桂珍
机构地区 哈尔滨商业大学生命科学与环境科学研究中心 东北林业大学材料科学与工程学院
出处 《天然产物研究与开发》 CAS CSCD 2007年第B11期459-461,共3页 Natural Product Research and Development
基金 黑龙江省自然科学基金项目（C200604） 哈尔滨商业大学研究生创新基金项目
关键词 桦木酸 细胞凋亡 细胞周期 抗肿瘤作用 betulinic acid cell apoptosis cell cycle antitumor
分类号 R285 [医药卫生—中药学]
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参考文献12

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共引文献35

同被引文献5

  • 1倪明宇,马莉,吴英良,李辉.桦木酸的抗肿瘤作用及其诱导KB细胞凋亡的研究[J].沈阳药科大学学报,2006,23(1):38-42. 被引量：14
  • 2Dimch VM, Stuppner H, Vollmar AM. Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overex- pression of Bcl-x(L) or Bel-2. Cancer Res, 2001,61 ( 15 ) : 5817- 5823.
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天然产物研究与开发
2007年 第B11期

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