Survivin在肺癌细胞定位表达与临床病理特征的关系

Expression of survivin and its location in cell and its relationship with clinicopathological features in the nonsmall cell lung carcinoma

目的:探讨survivin在肺癌细胞定位表达与临床病理特征的关系。方法:以免疫组化方法测定2004年1月￣2007年5月手术获得的50例肺癌标本survivin细胞定位情况,用SPSS软件χ2检验分析survivin细胞定位与患者年龄、性别、癌组织学类型、分化程度、TNM分期、淋巴结转移的关系。结果:50例肺癌标本中survivin总阳性率为62.0%(31/50),其中单纯胞质阳性占51.61%(16/31),单纯胞核阳性占25.8%(8/31),胞质和胞核共同阳性者占22.58%(7/31);survivin在肺癌细胞定位表达与淋巴结转移比较差异有显著性(P<0.005);而与患者年龄、性别、癌组织学类型、分化程度、TNM分期比较差异无显著性(P>0.005)。结论:survivin在肺癌细胞定位表达与肺癌淋巴结转移有关。

Objective：To study the expression of survivin and its location in cell and its relationship with elinieopathological features in the nonsmall cell lung carcinoma. Methods：The expression of survivin and its location was examined by immunohistochemieal method in the specimens of 50 eases of NSCLC.The relationship between the expression of survivin and its location and the age,sex,histologi- cal types,differentiation,P-TNM stage,lymph nodes metastases was analysed by using the X^2 test.Results ：The urvivin protein expression rate was 62.0% in 50 eases of NSCLC. The expression rate of survivin was 51.61%（8/31） in cytoplasm and 25.8%（16131） in nucleus. The expression rate of survivin was 22.58%（7/31） in cytoplasm and nucleus.The expression of survivin and its location in cell was significantly associated with lymph nodal metastases （P〈0.005）,but not with the age,sex,histological types,differenfiation,P-TNM stage （P〉 0.005）.Conclusion ：The different expression of survivin in nucleus and cytoplasm would be related with lymph nodal metastases.