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Aiolos基因对淋巴细胞影响的认识及进展 被引量:1

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摘要 Aiolos属于Ikaros家族成员,是表达在淋巴细胞内的转录因子,对淋巴细胞生长、分化和功能维持起重要作用,目前发现该家族包括Ikaros、Aiolos、Helios、Eos和Pegasus,前3个成员是淋巴细胞发育必要的转录因子。以下就Aiolos基因的结构特点、对T/B淋巴细胞的影响和作用机制等进行概述。
出处 《上海医学》 CAS CSCD 北大核心 2008年第1期73-75,共3页 Shanghai Medical Journal
基金 上海市自然科学基金重点资助项目(04JC14048)
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参考文献15

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同被引文献12

  • 1黄丽群,薛峰,沈小雁,郑捷.系统性红斑狼疮患者转录因子T-bet和GATA3基因的表达[J].中华皮肤科杂志,2004,37(12):724-726. 被引量:7
  • 2袁亚平,周敏,万欢英.Aiolos基因与支气管哮喘的关系[J].国际呼吸杂志,2006,26(8):574-576. 被引量:2
  • 3Rebollo A,Schmitt C.Ikaros ,Aiolos and Helios:transcription regulators and lymphoid maliganancies[J].Immunol CellBiol,2003,81 ( 3 ) : 171 - 175.
  • 4Grevink ME,Horst G,Lim brg PC,et al.Levels of complement in serafrom inactive SLE patients,although decreased ,do not influence in vitroup take of apoptotic cells[J].Autoimmunity,2005,24(4) :329.
  • 5Harley IT,Kafman KM,Langefeld CD,et al.Genetic susceptibility to SLE:new insights from fine mapping and genome-wide association studies[J].Nat Rev Genet,2009,10(5) :285 - 290.
  • 6Gortes M,Georgopolos K.Aiolos is reqired for the generati on of high affinit y bone marrow plasma cells responsible for longterm immnity[J].J Exp Med,2004, 1991:209-219.
  • 7Wang JH, AvitahlN, Cariappa A, et al. Aiolos regulates B cell activation and maturation to effector state [ J ]. Immunity, 1998, 9 (4) : 543 - 553.
  • 8Kikuchi H,Yamashita K, Nakayama M, et al. Lacking of Aiolos accelerates pre-mature B cell apoptosis mediated by BCR signaling through elevation in cytochrome c release[ J]. Biochim Biophys Acta,2009,1793 (7) :1304 - 1314.
  • 9Sun J, Matthias G, Mihatsch MJ,et al. Lack of the transcription alco activator OBF-1 prevents the development of systemic lupus erythematosus like phenotypes in Aiolos mutant mice [ J]. J Immunol, 2003, 170 (4) :1699 - 1706.
  • 10王秀宏.系统性红斑狼疮女性患者血清免疫球蛋白和补体与年龄的关系[J].中国皮肤性病学杂志,2011,25(7):524-526. 被引量:2

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