摘要
众所周知,促红细胞生成素(erythropoietin,EPO)直接促红细胞生成作用已被很好地研究和广泛应用。新近研究报道:EPO可显著改善心力衰竭,具有广泛的心血管系统保护作用,其抑制细胞凋亡作用开辟了临床研究和治疗的新视野。EPO挽救急性冠脉综合征的损伤心肌、限制心肌梗死面积、促进心功能恢复只是其抑制细胞凋亡多种潜在作用之一。具有选择性抑制细胞凋亡作用的EPO衍生物可能具有极好的研究应用前景。在心力衰竭和缺血性心脏病领域,增加EPO作为常规治疗可能有益。现将EPO对心血管系统作用的研究作一综述。
The direct erythropoietie action of erythropoietin （EPO） is well studied and widely used. Published studies report dramatic improvement in the c.ourse of heart failure with EPO treatment and wide-ranging cardiovascular protective effects of EPO. Antiapoptotic effects of EPO open new horizons in both clinical investigation and therapy. The salvage of cardiomyoeytes in acute coronary syndromes, limiting the size of myocardial infarction and improving functional recovery, is only one of multiple potential applications of this effect. Derivatives of EPO with selective antiapoptotic properties seem to hold the best prospects for tuture studies, Heart failure and ischemic heart disease are potential areas where adding EPO to the conventional treatment may be beneficial. This article reviews the studies about cardiovascular effects of EPO.
出处
《心血管病学进展》
CAS
2008年第1期139-141,共3页
Advances in Cardiovascular Diseases
