奎硫平、利培酮和氯氮平对精神分裂症血清催乳素的影响比较

The effects of Quetiapine,Risperidone and Clozapine for schizophrenia on serum prolactin level

目的:评价奎硫平、利培酮、氯氮平对精神分裂症血清催乳素的影响。方法:对117例年龄18～65岁的精神分裂症的患者,随机分成3组,分别用奎硫平、利培酮、氯氮平进行治疗,疗程8周,采用多功能生化分析仪性激素试剂盒ELISA法检测血清催乳素含量,用阳性症状与阴性症状量表(PANSS)评定疗效。结果:奎硫平组、利培酮组血清催乳素均增高,氯氮平组血清催乳素没有显著变化。结论:血清催乳素监测,作为非典型抗精神病药疗效的指标有待观察。

Objective：To assess the serum prolactin levels of schizophrenia treated by of Quetiapine,Risperidone and Clozapine. Methods：ELISA had been used to determine the serum prolactin levels. Results： The serum prolactin levels Quetiapine treated and Risperidone treated patients increased significantly 8 weeks later,while those of Clozapine-treated patients showed no obvious change. Conclusions： The serum prolactin levels can＇t predict the clinical outcome of atypical antipsychotics.