头孢噻肟钠和头孢他美酯片序贯疗法治疗女性泌尿系统感染疗效观察

Switch Therapy with Cefotaxime Sodium and Cefetamet in Female Patients with Urinary Tract Infection

目的:评价头孢噻肟钠和头孢他美酯片序贯疗法治疗中～重度女性泌尿系统感染的疗效和安全性。方法:119例患者按住院号随机分为混合组和单用组。混合组先给予头孢噻肟钠3g+生理盐水100mL,静脉滴注,2次.d-1;治疗3d后改用头孢他美酯片250mg,口服,2次.d-1。疗程7～14d。单用组给予头孢噻肟钠3g+生理盐水100mL,静脉滴注,2次.d-1,治疗7～12d。结果:2组平均好转天数、痊愈率、有效率、细菌清除率比较无显著性差异(P>0.05),但平均费用混合组明显低于单用组(P<0.05)。结论:头孢噻肟钠和头孢他美酯片序贯疗法治疗中～重度女性泌尿系统感染安全、有效、经济。

OBJECTIVE： To evaluate the curative efficacy and safety of the switch therapy with Cefotaxime Sodium and cefetamet in the treatment of female patients with moderate to severe urinary tract infection.METHODS： A total of 119 cases were randomly divided into two groups according to their admission numbers：the combined therapy group was treated i.v.with cefotaxime（3 g） ＋ NS（100 mL） b.i.d for 3days, followed by cefetamet tablets 250 nag per os b.i.d for 7 -14 days, while the single therapy group was treated i .v. with cefotaxime（3 g） ＋ NS（100 mL） b .i .d alone for 7-12 days .RESULTS：There were no significant differences between two groups in average days of improvement, cure rates, effective rates and bacterial clearance rates（P 〉0.05）, however, the average cost in combined group was significantly lower than in single group（P 〈 0.05） .CONCLUSION： The switch therapy with Cefotaxime Sodium and cefetamet was proved to be safe, economical and effective for moderate to severe infection of female urinary system.