脑卒中后抑郁与血清细胞因子的相关性

Relationship between Post-stroke Depression and Serum Cytokines

目的:探讨血清细胞因子IL-1β、IL-6、TNF-α与脑卒中后抑郁的相关性。方法:采用酶联免疫吸附法(ELISA)对脑梗死(对照组)及脑梗死后抑郁(研究组)患者各32人在脑梗死后第7和28天分别检测血清IL-1β、IL-6及TNF-α水平。结果:对照组患者第7和第28天的IL-1β、IL-6、TNF-α水平差异无统计学意义(P>0.05)。脑卒中后抑郁组第28天的血清IL-1β、IL-6及TNF-α水平显著高于无抑郁的对照组?41.0±4.4/17.6±3.2,13.5±4.1/5.4±2.0,34.5±7.6/20.8±4.3,P<0.01?,亦显著高于研究组发病第7天的血清水平(17.3±3.5,5.7±2.0,21.1±4.3,P<0.01?;脑卒中后重度抑郁组血清IL-1β、IL-6及TNF-α水平(42.6±3.5,18.7±6.3、39.0±6.4)显著高于轻度抑郁组(28.7±2.5,6.8±1.7、26.4±3.2)及中度抑郁组?34.3±2.8,9.9±3.4、31.5±3.5,P<0.01?,中度抑郁组亦高于轻度抑郁组(P<0.05?。结论:IL-1β、IL-6及TNF-α可能在脑卒中后抑郁的发病机理中起着重要作用。

Objeαive： To investigate the relationship between serum cytokines （IL-1β, IL-6 and TNF-α） and post-stroke depression. Methods： Serum IL-1β, IL-6 and TNF-α in stroke patients （ n = 32） and post-stroke depressive patients （ n = 32 ） were measured by ELISA on day 7 and day 28 after stroke. Results： The serum levels of IL-1 β, IL-6 and TNF-α of the study group in day 28 were higher than that of control group { 41.0 ＋ 4.4/17.6 ＋ 3.2, 13. 5 ±4. 1/5.4 ±2. 0, 34. 5 ±7.6/20. 8 ±4. 3, P 〈 0.01 }, and increased than that in the 7th day （17.3 ± 3. 5, 5.7 ±2.0, 21.1 ±4. 3, P 〈0.01 ） ; In the study group, the serum levels of IL-1β, IL-6 and TNF-α in those with serious depression were higher than that in moderate and mild depression groups （42. 6 ±3. 5, 18. 7 ±6. 3, 39. 0 ±6. 4, 34.3 ±2.8, 9.9±3.4, 31.5±3.5, 28.7 ±2.5, 6.8±1.7, 26.4 ±3.2, P〈0.01）, and that in moderate depression group were higher than that in mild depression group （all P 〈 0. 05 ） . Conclusion. IL-1β, IL-6 and TNF-α maybe play an important role in pathogenesis of post-stroke depression.