LASEK+MMC治疗近视的临床疗效

The clinical effect of applying mitomycin C in LASEK surgery

目的探讨丝裂霉素C(MMC)对准分子激光上皮下角膜磨镶术(LASEK)后角膜上皮下雾状混浊(haze)与屈光回退等方面的影响。方法将接受LASEK手术的患者先分为低中度数组(等效球径值<-6.00D)和高度数组(等效球径值>-6.00D),再将低度数组随机分为常规方法LASEK(组E①,90只眼)和LASEK+MMC(组M①,92只眼),将高度数组随机分为常规方法LASEK(组E②,96只眼)和LASEK+MMC(组M②,104只眼)。分别观察两组患者中两种手术方式术后疼痛、角膜上皮愈合时间、haze程度以及屈光回退度数情况,加以对比。结果常规LASEK术后haze程度明显重于LASEK+MMC,P<0.05;术后疼痛、角膜上皮愈合速度常规LASEK与LASEK+MMC无显著性差异,P>0.05;屈光回退度数在低中度数组,两种手术方式无显著性差异,P>0.05,在高度数组LASEK+MMC明显小于常规LASEK,P<0.05。结论MMC应用于LASEK术中能够减轻haze的形成,减少屈光回退的发生,尤其对高度数近视值得推广使用。

Objective To protect the effect of using mitomycin C on the occurrence of hazeunder corneal epithelium and refractive outcomes in LASEK surgery. Methods The patients who accepted LASEK were firstly divided into the groups of isoeffect spherical≤-6.00D and the groups of isoeffect spherical〉-6.0OD. Secondly the groups of isoeffect spherical ≤-6DOD were randomly divided into 90 eyes of 45 cases of conventional LASEK （greupE（1））, 92eyes of 46 cases of MMC＋LASEK （group M（1）;, the groups of isoeffect spberical〉-6.00D were randomly divided into 96 eyes of 48 cases of conventional LASEK （groupE（2）, 104 eyes of 52 cases of MMC＋LASEK （group M（2）. Observe and compare the postoperative pain, recovery of corneal epithelium, the degree of haze and the stability of the recovery of visual acuity. Results Haze in MMC＋LASEK group is light than conventional LASEK group, P〈0.05. There was no significant difference in postoperative pain, recovery of corneal epithelium between two groups, P〉0.05. There was no significant difference in refractive outcomes between two groups in low myopia group, P〉0.05. But in high myopia group, refractive outcomes were lower in MMC＋LASEK group after six months of operation, P〈0.05. Conclusions The application of MMC during LASEK operation could reduce the formation of haze and refractive outcomes. It＇s worth to be generalized, especially in high myopia.