合成呋喃酚中主要副产物的分离与结构鉴定

Separation of the Main by-Product from 2-(2-Methylallyloxy)phenol and Its Identification

为了探索和确证邻苯二酚路线合成呋喃酚的反应过程。分离了合成呋喃酚中的主要杂质,通过1HNMR和LC-MS确定其结构为4-(2-甲基烯丙基)-1,2-苯二酚。推出了该反应可能的机理。采用异戊醇铝催化合成呋喃酚,收率达到79.88%,高于工业化装置的收率78.30%。

In order to explore and confirm the process of benzofuranol synthesized from catechol, 4-（2-methylallyl） benzene-1,2-diol, the main by-product in the synthesis of benzofuranol, was separated and the structure was identified by ^1H NMR and LC-MS. Accordingly, the likely mechanism of this reaction was proposed. By employing aluminium isoamoxide as catalyst, the yiled of cyclization is improved to 79.77%, which is higher than that of 78.30% in commercial installation.