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高空缺氧条件下DPH对脑铁、锌及MDA含量的影响

Effect of DPH on the Content of Fe, Zn and MDA in Brain under High-altitude Condition
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摘要 用原子吸收法测定了高空缺氧条件下DPH对大鼠脑组织铁、锌含量的影响.并测定了脑MDA含量。结果显示:对照组在高空缺氧条件下.脑组织铁含量明显高于用药组P<0.05).而脑锌含量明显低于用药组(P<0.05)。脑组织MDA含量明显高于地面对照组及用药组(P<0.01)。这表明,在高空缺氧条件下,对照组脑组织过氧化反应增强,高于用药组;脑组织MDA含量与锌含量成反比。 The content of Fe and Zn in brain of rats with or without DPH in 7. 5 km high-altitudedetermined by atondc absorption spectrometry. The content of the brain MDA was also observed. The results showed that the content of brain FE in rat without DPH under hith-alti-tude was much higher than that of normal rat and the content of brain Zn of rat with DPHwas much higher than that of rat without DPH under high-altitude. The content of rat brainMDA without DPH was much higher than that of rat with DPH under high-altitude. The oxgen deficiency makes brain metabolism and hydroperoxidate reaction increased while.DPHmakes brain metabolism and hydroperoxidate reaction decreased.
出处 《广东微量元素科学》 CAS 1997年第8期17-19,共3页 Trace Elements Science
关键词 苯妥英钠 高空缺氧 脑组织 丙二醛 Dephenylhydantion (DPH), High-altitude,Atomic absorption spectrometry
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  • 1J. Suzuki,H. Abiko,K. Mizoi,M. Oba,T. Yoshimoto. Protective effect of phenytoin and its enhanced action by combined administration with mannitol and vitamin E in cerebral ischaemia[J] 1987,Acta Neurochirurgica(1-2):56~64

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