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左氧氟沙星四联根除幽门螺杆菌疗效观察 被引量:2

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摘要 目的:探讨左氧氟沙星在根除幽门螺杆菌(Hp)中的效果。方法:选择242例Hp阳性胃、十二指肠溃疡患者,随机分为观察组和对照组各121例,观察组给予泮托拉唑、阿莫西林、左氧氟沙星、枸橼酸铋钾口服,2次/d。对照组给予泮托拉唑、阿莫西林、甲硝唑、枸橼酸铋钾口服,2次/d。疗程均为7 d。结果:观察组与对照组的Hp根除率分别为92.3%和71.9%,两组有显著性差异(P<0.05);溃疡愈合率分别为94.2%和93.4%,两组无显著性差异(P>0.05)。结论:左氧氟沙星四联根除Hp疗程1周,Hp根除率可达90%以上,疗效好,副作用低,是值得考虑的根除Hp的药物选择。
作者 李宝祥
出处 《中国误诊学杂志》 CAS 2008年第6期1288-1289,共2页 Chinese Journal of Misdiagnostics
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  • 1[1]Wong BC, Wong WM, Yee YK, et al.Rabeprazole-based 3-day and 7-day triple therapy vs. omeprazole-based 7-day triple therapy for the treatment of Helicobacter pylori infection[J].Aliment Pharmacol Ther,2001,15(12):1959-1965.
  • 2[3]Nagahara A, Miwa H,Ogawa K,et al.Assition of Metronidazole to Rabeprazole-Amoxicillin-Clllarithromycin Regimen for Helicobacter pylori infection Provides an Excellent Cure Rate with Five-Day therapy[J]. Helicobacter,2000,5(2):88-93.
  • 3[4]Treiber G,Ammon S.Amoxicillin,metronidazole,omeprazole,clarithromycin:a new,short quadruple therapy for Helicobacter pylori eradication[J].Helicobacter.1998,3(1):54-58.
  • 4[5]Richardson P,Hawkey CJ,Stack WA.Proton pump inhititors:Pharmacology and rationale for use in gastrointestinal disorders[J].Drugs,1998,56(3):307-335.(Review)
  • 5[6]Sachs G,Shin JM, Briving C,et al. The pharmacology of the gastric acid pump:the H+,K+ATPase [J].Annu Rev Pharmacol Toxicol,1995,35:277-305.(Review)
  • 6[7]Kawakami Y,Akahane T, Yamaguchi M, et al.In vitro activities of rabeprazole,a novel proton pump inhibitor and its thioether derivative alone and combination with other antimicobials against recent clinical isolates of Helicobacter pylori [J].Antimicrob Agents Chemother ,2000,44(2):458-461.
  • 7[8]Stone GG, Shortridge D, Flamm RK, et al. Identification of a 23S rRNA gene mutation in clarithromycin-resistance Helicobacter pylori[J]. Helicobacter,1996,1(4):227-228.
  • 8[9]Versalovic J, Shortridge D, Kibler K, et al. Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori[J]. Antimicrob Agents Chemother,1996,40(2):477-480.
  • 9[10]European study group on antibiotic susceptibility of Helicobacter pylori. Results of a multicentre European survey in 1991 of metronidazole resistance in Helicobacter pylor[J]. Eur J Clin Microbiol Infect Dis,1992,11(9):777-781.
  • 10[11]Jenks PJ, Labigne A, Ferrero RL. Exposure to metronidazole in vivo readily induces resistance in Helicobacter pylori and reduces the efficacy of eradication therapy in mice[J]. Antimicrob Agents Chemother,1999,43(4):777-781.

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