肠镜检查应用镇静剂的有效性分析

Efficacy of Colonoscopy with Sedatives

【目的】探讨肠镜检查前镇静荆预处理的有效性及患者对肠镜检查的耐受性相关性因素。【方法】采用随机双盲安慰荆对照研究，对201例接受肠镜检查的患者采用logistic回归方法分析镇静荆、焦虑和其他潜在的相关因素与患者检查不适程度的相对危险度（RR）。【结果】与安慰荆组比较，镇静荆组患者在肠镜插入时不适的RR为0．56（95％CI，0．31～1．01），便秘患者肠镜插入时不适RR较无便秘的患者高（RR=2．22，95％CI 1．04～4．74）；腹部手术史者（除外结肠切除术）接受肠镜检查患者发生不适的RR为0．20（95％CI 0．04～0．93）。【结论】对便秘和腹部手术史（除外结肠切除术）接受肠镜检查者镇静荆能明显减轻不适，而焦虑特性与患者不适程度间无相关性。

[Objective]To evaluate the efficacy of sedative precomditioning before colonoscopy and some factors associated with patients＂ tolerance. [Methods]Two hundred and one patients were investigated by randomized doubleblind control study. Logistic regression analysis was used to evaluate the relative risk （RR） between sedatives, anxie- ty, other related factors and the degree of patients＂ uncomfortable [Results]The RR was 0. 56（95% CI,0. 31-1.01） in the sedative group. The RR （RR=2.22,95%CI 1.04-4.74） of uncomfortable caused by colonscope insertion in patients with constipation was higher than that of patients without constipation. The RR of uncomfortable in patients with surgical history was 0. 20（95%CI 0.04-0. 93）. [Conclusion]Sedatives could significantly decrease uncomfortable during colonoscopy in patients with constipation or surgical history. There was no association between the degree of uncomfortable and the character of anxiety.