头孢西酮钠对临床分离细菌感染小鼠的保护作用

The effect of cefazedone sodium on mice infected by clinically isolated bacteria

目的探讨头孢西酮钠对临床分离菌株感染小鼠的保护作用。方法给小鼠腹腔注射临床分离的金黄色葡萄球菌、铜绿假单胞菌和大肠埃希菌,感染后皮下注射头孢西酮钠,观察记录感染后小鼠的生存率。结果头孢西酮钠10mg/kg、20mg/kg和40mg/kg能显著降低中间葡萄球菌R1725株、金黄色葡萄球菌R1743株、铜绿假单胞菌R1620株、铜绿假单胞菌R1598株、大肠埃希菌R1598株、大肠埃希菌W1867株和D群肠球菌W1999株感染小鼠的死亡率。结论头孢西酮钠对临床分离的金黄色葡萄球菌、铜绿假单胞菌和大肠埃希菌感染小鼠有显著的保护作用。

Objective To study the effect of cefazedone sodium on mice infected by clinically isolated bacteria. Methods The mice were injected clinically isolated strains of staphylococcus aureus, pseudomonas aeruginosa（ P. aeruginosa）and escherichia coli by intraperitoneal route. Then the infected mice were injected cefazedone sodium by subcutaneous route. Results Cefazedone sodium of 10 mg/kg,20 mg/kg and 40 mg/kg decreased the mortality rate of mice infected by staphylococcus intermediu R1725, staphylococcus aureus 1743, pseudomonas aeruginosa R1620, pseudomonas aeruginosa R1598, escherichia coli R1598, escherichia coli W1867 and enterococci W1999. Conclusion Cefazedone sodium can protect mice infected by clinically isolated staphylococcus aureus,pseudomonas aeruginosa,and escherichia coli.