血清CA125及CA19-9联合测定对子宫肌瘤及子宫腺肌病的诊断价值

The diagnostic value of CA125 and CA19-9 in serum for leiomyoma and adenomyosi

目的探讨血清CA125、CA19-9联合测定对子宫肌瘤及子宫腺肌病的检测及意义。方法采用电化学发光免疫法测定子宫腺肌病患者49例、子宫肌瘤患者32例血清中CA125、CA19-9水平。结果子宫腺肌病组CA125值显著高于子宫肌瘤组,(P<0.01)。CA125在子宫腺肌病组中阳性率为79.59%,其敏感性、特异性、阳性预测值、阴性预测值分别为:76.5%、93.4%、92.1%、78.3%,CA19-9值与子宫肌瘤组差异无显著性。结论子宫腺肌病血清中CA125升高,对子宫腺肌病有较好的诊断预测价值。

Objective To compare the diagnostic value of CA125 ,CA19-9 in serum for leiomyoma and adenomyosis. Methods 49 cases of adenomyos （ group A） and 32 cases with leiomyoma （ group B） were measured with immunoradiologic method. Cancer antigen 125 （ CA125 ） , canbohydrate antigen 19-9 （ CA19-9 ）. Resuits The level of CA125 in group A was significantly higher than that in group B （ P 〈 0.01 ）. The positive rate of CA125 in group A was 79.59% ,the sensitivity, specificity, positive predictive value and negative predivtive value of CA125 ,in group A was 76. 5% ,93.4% ,92. 1% ,78.3% , there was no statistically significant difference in the level of CA19-9 between 2 groups （ P 〉 0. 05 ）. Conclusion The senum levels of CA125 significantly ascend in paients with adenomyosis. CA125 may be a better predicting marker for clinical diagnosis of adenomyosis.