CD105在乳腺微浸润和浸润性导管癌表达的研究

The research of CD105 expression in breast MDC and IDC

目的检测CD105在乳腺微浸润导管癌(MDC)和非特殊类型浸润性导管癌(IDC,NOS)的表达情况,探讨新生血管在乳腺癌发生发展中有一定的作用。方法采用免疫组织化学、RT-PCR方法检测CD105在MDC和IDC(NOS)病变中的表达。结果2种方法提示CD105在2种病变中表达有显著性的差异。结论CD105用来评估乳腺癌发展中的新生血管表达,这将为今后抗血管生成抑制剂的临床应用提供理论依据。

Objective Purpose To detect the expression of CD105 in MDC and IDC （NOS） of breast carcinoma,evaluate the neonatal vessel in evolution of breast carcinoma. Methods In the MDC and IDC （NOS） of breast carcinoma,the expression of CD105 was examined by immunohistochemistry and RT-PCR. Results There existed a significant diffience of CD105 in MDC and IDC （NOS）by both examinations. Conclusion It is valuable that using CD105 to detect neonatal vessel in progress of breast carcinoma,it will provide theoretical evidence for the clinical anti-vessel inhibitor application.