抗生素相关性腹泻临床特征分析

Clinical characteristic analysis of antibiotic-associated diarrhea

目的了解医院感染抗生素相关性腹泻(AAD)的临床特点,提出预防控制措施。方法回顾性分析2005年1月至2007年11月儿科住院患儿4357例,获得医院感染抗生素相关性腹泻57例,与医院感染非抗生素相关性腹泻12例作对照分析。结果医院感染抗生素相关性腹泻较非抗生素相关性腹泻发病率高、临床症状重;致病菌中主要为G+菌和真菌,抗生素使用时间≥5d,腹泻感染率明显升高,联合使用抗生素种类越多,腹泻感染率越高。结论规范抗生素的应用,严格控制广谱抗生素的使用和补充微生态制剂,是预防控制医院感染抗生素相关性腹泻的关键措施。

Objective To investigate the clinical characteristic of antibiotic-associated diarrhea in nosocomial infection and make measures to prevent and control it. Methods The clinical data of 4 357 hospitalized children from Jan 2005 to Nov 2007 were analyzed. 57 cases of antibiotic-associated diarrhea in nosocomial infection were given and analyzed in comparison with 12 cases of non-antibiotic-associated diarrhea in nosocomial infection. Results There were more incidence and clinical symptoms in antibiotic-associated diarrhea than that in non-antibiotic one in nosocomial infection. The main pathogens were Gram-positive bacteria and fungi. Infection rate of diarrhea increased while the antibiotics were used more than five days. The more antibiotics were used, the more infection rate of diarrhea was. Conclusion Norm application of antibiotic, rigorous control use of antibiotic and additional microeconogic were the key measures to prevent and control the antibiotic-associated diarrhea in nosocomial infection.