N-甲基-2-(4-羟基苯基)[60]富勒烯吡咯烷衍生物的合成研究

Study on synthesis of N-methyl-2-(4-hydroxyphenyl)[60]fullerene pyrrolidine

利用肌氨酸和对羟基苯甲醛所形成的亚胺叶立德与C60发生1,3-偶极环加成反应,合成了一种新型含羟基C60吡咯烷衍生物:N-甲基-2-(4-羟基苯基)[60]富勒烯吡咯烷。通过UV-vis1、H-NMR、MS、FT-IR确定了产物的结构。探讨了反应条件对产物产率的影响,得到了最佳工艺条件:反应物摩尔比为1∶2∶6,温度为90℃,反应时间为5h,此时产物的产率可达到87%(以消耗的C60计)。

A new compound N-methyl-2-（4-hydroxyphenyl）[60] fullerene pyrrolidine was synthesized by the 1,3- dipolar cycloaddition reaction between the fullerene（C60） and azomethine ylide （prepared from sarcosine and phydroxybenzaldehyde）. The product was characterized by UV-vis,^1H-NMR, MS and FI-IR. The reaction conditions affecting the yields of product were investigated and the optimum reaction conditions which affored 87 （based on consumed C60）of product are： molar ratio of C60：p-hydroxybenzaldehyde： sarcosine 1：2：6, reaction temperature 90℃, reaction time 5h.