免疫学检测与自身免疫性肝病相关性研究

Study on Immunological Feature of Autoimmune Hepatic Diseases

目的分析自身免疫性肝病的免疫学特点,以提高对该类疾病的认识和诊断水平。方法对164例自身免疫性肝病患者免疫学检查资料进行回顾性分析。结果原发性硬化性胆管炎(PSC)多发于青年男性,自身免疫性肝炎(AIH)、原发性胆汁性肝硬化(PBC)及其重叠綜合症(AIH-PBC)多发于女性。AIH、PBC、PSC和AIH-PBC肝外自身免疫性疾病的发生率分别为47%、11%、27%和24%,各自身免疫性肝病患者均有较高的自身抗体发生率。结论自身免疫性肝病在临床上并不少见,患者常伴发肝外自身免疫性疾病及较高的自身抗体发生率。

Objective To analyze the immunological characteristics of the autoimmune hepatic diseases in hope to enhance the understanding of the disease and increase the diagnosis level. Methods The clinical manifestation and the immunological tests were investigated retrospectively in 164 patients with autoimmune hepatic diseases. Results The primary sclerosing cholangitis （PSC） affected mainly the young men,but the autoimmune hepatitis（AIH） ,primary biliary cirrhosis（PBC） and AIH-PBC overlap syndrome frequently affected middle-aged women. The incidence rate of AIH, PBC, PBC and PBC-AIH overlap syndrome were 47% , 11% ,27% and 24% respectively in autoimmune disorders extra liver. The patients with these autoimmune hepatic diseases were all with high rate of auto-antibody. Conclusions Autoimmune hepatic diseases often associate with extra liver immune disorders and a high rate of auto - antibody.