期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肉毒碱/有机阳离子转运体基因多态性与克罗恩病相关性的研究进展 被引量：3

Development of Relationship between Carnitine/Organic Cation Transporter Gene Polymorphism and Crohn's Disease
下载PDF
导出
摘要 克罗恩病(CD)是肠道慢性、节段性、透壁性、肉芽肿性炎症性疾病,其发病机制尚未明确,但遗传因素在CD的发病中起重要作用。近年研究将位于5号染色体上的肉毒碱/有机阳离子转运体(OCTN)1和OCTN2确认为CD易感基因,本文就OCTN基因多态性与CD相关性的研究进展作一综述。 Crohn＇s disease （CD） is an inflammatory bowel disease characterized by chronic, segmental, transmural, and granulomatous inflammation, its pathogenesis remains unclear, however, genetic factor plays an important role in the pathogenesis of CD. Recent studies have identified carnitine/organic cation transporter （OCTN） 1 and OCTN2 on chromosome 5 as the CD susceptibility genes. This review article introduced the development of relationship between OCTN gene polymorphism and CD.
作者 卢战军 郑萍
机构地区 上海交通大学附属第一人民医院消化内科
出处 《胃肠病学》 2008年第1期61-63,共3页 Chinese Journal of Gastroenterology
关键词 CROHN病 肉碱 有机阳离子转运子1 多态现象 遗传 Crohn Disease Carnitine Organic Cation Transporter 1 Polymorphism, Genetic
分类号 R574 [医药卫生—消化系统]
  • 相关文献

参考文献3

二级参考文献32

  • 1Elena Urcelay,Juan Luis Mendoza,Alfonso Martínez,Laura Fernández,Carlos Taxonera,Manuel Díaz-Rubio,Emilio G.de la Concha.IBD5 polymorphisms in inflammatory bowel disease: Association with response to infliximab[J].World Journal of Gastroenterology,2005,11(8):1187-1192. 被引量：4
  • 2[1]Bonen DK,Cho JH.The genetics of inflammatory bowel disease.Gastroenterology 2003;124:521-536
  • 3[2]Ahmad T,Tamboli CP,Jewell D,Colombel JF.Clinical relevance of advances in genetics and pharmacogenetics of IBD.Gastroenterology 2004;126:1533-1549
  • 4[3]Hugot JP,Laurent-Puig P,Gower-Rousseau C,Olson JM,Lee JC,Beaugerie L,Naom L Dupas JL,Van Gossum A,Orholm M,Bonaiti-Pellie C,Weissenbach J,Mathew CG,Lennard-Jones JE,Cortot A,Colombel JF,Thomas G.Mapping of a susceptibility locus for Crohn's disease on chromosome 16.Nature 1996;379:821-823
  • 5[4]Cavanaugh J.International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set:Crohn disease and chromosome 16.Am J Hum Genet 2001;68:1165-1171
  • 6[5]Zouali H,Chamaillard M,Lesage S,Cezard JP,Colombel JF,Belaiche J,Almer S,Tysk C,Montague S,Gassull M,Christensen S,Finkel Y,Gower-Rousseau C,Modigliani R,Macry J,Selinger-Leneman H,Thomas G,Hugot JP.Genetic refinement and physical mapping of a chromosome 16q candidate region for inflammatory bowel disease.Eur J Hum Genet 2001;9:731-742
  • 7[6]Brant SR,Panhuysen CI,Bailey-Wilson JE,Rohal PM,Lee S,Mann J,Ravenhill G,Kirschner BS,Hanauer SB,Cho JH,Bayless TM.Linkage heterogeneity for the IBD1 locus in Crohn's disease pedigrees by disease onset and severity.Gastroenterology 2000;119:1483-1490
  • 8[7]Gazouli M,Zacharatos P,Mantzaris GJ,Barbatis C,Ikonomo poulos I,Archimandritis AJ,Lukas JC,Papalambros E,Gorgoulis V.Association of NOD2/CARD15 variants with Crohn's disease in a Greek population.Eur J Gastroenterol Hepatol 2004;16:1177-1182
  • 9[8]Gazouli M,Mantzaris G,Kotsinas A,Zacharatos P,Papalambros E,Archimandritis A,Ikonomopoulos J,Gorgoulis VG.Association between polymorphisms in the Toll-like receptor 4,CD14,and CARD15/NOD2 and inflammatory bowel diseasein the Greek population.World J Gastroenterol2005;11:681-685
  • 10[9]Ogura Y,Bonen DK,Inohara N,Nicolae DL,Chen FF,Ramos R,Britton H,Moran T,Karaliuskas R,Duerr RH,Achkar JP,Brant SR,Bayless TM,Kirschner BS,Hanauer SB,Nunez G,Cho JH.A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.Nature 2001;411:603-606

共引文献20

同被引文献31

  • 1刘涛,刘克辛.药物转运体的变化对肝脏疾病的影响[J].中华临床医师杂志（电子版）,2011,5(10):2982-2985. 被引量：4
  • 2Maria Gazouli,Gerassimos Mantzaris,Athanassios J Archimandritis,George Nasioulas,Nicholas P Anagnou.Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease[J].World Journal of Gastroenterology,2005,11(47):7525-7530. 被引量：12
  • 3Judit Bene,Lili Magyari,Gábor Talián,Katalin Komlósi,Beáta Gasztonyi,Beáta Tari,gnes Várkonyi,Gyula Mózsik,Béla Melegh.Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease[J].World Journal of Gastroenterology,2006,12(34):5550-5553. 被引量：6
  • 4S Cucchiara,A Latiano,O Palmieri,AM Staiano,R D'Incà,G Guariso,G Vieni,V Rutigliano,O Borrelli,MR Valvano,V Annese.Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases[J].World Journal of Gastroenterology,2007,13(8):1221-1229. 被引量：9
  • 5Yun Feng, Ping Zheng, Kai Wu, et al. SLC22A4 and SLC22A5 gene polymorphisms and Crohn's disease in Chinese Han population [J]. J Dig Dis,2009,10(3): 181 - 187.
  • 6You G, Morris M. Drug Transporters [ M]. New Jersey : John Wi-ley & Sons,Inc.,2007 : 1 -50.
  • 7Nies A,Koepsell H,Damme K. Organic cation transporters ( 0C-Ts, MATEs),in vitro and in vivo evidence for the importance indrug therapy[ J]. Handb Exp Pharmacol, 2011 ;201 :105 - 167.
  • 8Klaassen CD, Aleksunes LM. Xenobiotic, bile acid, and cholester-ol transporters : function and regulation [ J ]. Pharmacol Rev t 2010 ;62:1 -96.
  • 9Matsuzaki T, Morisaki T, Sugimoto W, et al. Altered pharmacoki-netics of cationic drugs caused by down - regulation of renal rat or-ganic cation transporter 2 ( Slc22a2) and rat multidrug and toxin ex-trusion 1 ( Slc47al ) in ischemia/reperfusion - induced acute kidneyinjury[ J]. Drug Metab Disposit :Biol Fate Chem,2008 ;36 ;649 -654.
  • 10Dantzler WH. The use of mammalian cortical kidney slices for thestudy of tubule secretion: a pioneering step toward understanding or-ganic anion transport[ J]. Am J Physiol Renal Physiol,2006 ;290 : 1-3.

引证文献3

二级引证文献2

胃肠病学
2008年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部