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系统性红斑狼疮患者CD4^＋、CD8^＋T淋巴细胞SLAM基因的表达分析 被引量：3

Expression of SLAM gene in CD4^+ and CD8^+ T cells from SLE patients
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摘要 目的探讨系统性红斑狼疮(systemic lupus erythematosus,SLE)患者CD4+、CD8+T淋巴细胞SLAM基因的表达。方法采用免疫磁珠的方法对20例系统性红斑狼疮患者及10例正常人外周血CD4+、CD8+T淋巴细胞进行分离,RT-PCR对CD4+、CD8+T淋巴细胞SLAM基因表达进行分析。结果SLE患者CD4+、CD8+T淋巴细胞SLAM mRNA表达增加显著高于正常对照。结论SLAM介导的T淋巴信号通路转导异常可能在SLE患者T淋巴细胞激活异常中发挥重要的作用。 Objective To explore the expression of SLAM gene in the CD4^＋ and CD8^＋ T cells from SLE patients. Method The CD4^＋ and CD8^＋ T cells from peripheral blood of 20 SLE patients and 10 healthy blood donors were separated using magnetic cell sorting system （MACS）. We detected the expression of SLAM mRNA in CD4^＋ and CD8^＋ T cells by RT-PCR. Results The CD4^＋ and CD8^＋ T cells from SLE patients showed significantly higher SLAM expression than those from healthy blood donors. Conclusion The SLAM signal pathway may play an important role in contributing to the abnormal activation of T cells in SLE patients.
作者 游弋 郝飞 邓永键
机构地区 第三军医大学西南医院皮肤科
出处 《第三军医大学学报》 CAS CSCD 北大核心 2008年第3期207-209,共3页 Journal of Third Military Medical University
基金 国家自然科学基金(30271199)~~
关键词 红斑狼疮 系统性 信号转导淋巴细胞激活分子 lupus erythematosus systemic SLAM
分类号 R392.12 [医药卫生—免疫学] R392.13 [医药卫生—免疫学]
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参考文献12

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二级参考文献14

共引文献6

同被引文献37

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引证文献3

二级引证文献22

第三军医大学学报
2008年 第3期

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