Atorvastatin attenuates oxidative stress in Alzheimer's disease

Objective： To investigate serum level of SOD, MDA, ox-LDL, AchE and Ach in AD, to study atorvastatin influence on serum level of SOD, MDA, ox-LDL, Ache and Ach in AD and its neuroprotection mechanisms. Methods Subjects were divided into： normal blood lipid level group with Alzheimer＇s disease （A）, higher blood lipid level group with Alzheimer＇s disease （AH）, normal blood lipid level Alzheimer＇s disease group with atorvastatin treeatment （AT）, higher blood lipid level Alzheimer＇s disease group with atorvastatin treeatment（AHT）. Ox-LDL was measured by enzyme linked immunosorbent assay; SOD, MDA, ox-LDL, AchE, Ach and blood lipid level in AD was measured by biochemistry. Results： The serum level of MDA, Ache in AH group after atorvastatin treatment is lower ;The serum level of SOD, Ach in AH group is more increased than that of in A group; The serum level of ox-LDL in AH, A groups is lower than that of in A group; The dementia degree is lower after atorvastatin treatment. Conclusion： Atorvastatin can decrease serum level of MDA, AchE and ox-LDL, and increase that of SOD, Ach, and attenuate dementia symptom in AD, especially, with hyperlipemia. The hypothesis of atorvastatin neuroprotection is concluded that atorvastatin may restrain free radical reaction and retard oxidation in AD.

ObjectiveTo 在广告调查草皮， MDA， ox-LDL，疼痛和 Ach 的浆液水平到对草皮的浆液水平的学习 atorvastatin 影响，在广告和它的 neuroprotection mechanisms.MethodsSubjects 的 MDA， ox-LDL，疼痛和 Ach 被划分成：有 Alzheimer 的疾病(A) 的正常的血类脂化合物水平组，有 Alzheimer 的疾病的更高的血类脂化合物水平组(啊) ，正常的血类脂化合物水平 Alzheimer 有 atorvastatin 治疗的疾病组(在) ，更高的血类脂化合物水平 Alzheimer 有 atorvastatin 治疗(AHT ) 的疾病组。Ox-LDL 被酶测量连接免疫吸着剂试金；在广告的草皮， MDA， ox-LDL，疼痛， Ach 和血类脂化合物水平被 MDA 的 biochemistry.ResultsThe 浆液水平测量，疼痛在啊在 atorvastatin 治疗以后的组更低；草皮的浆液水平， Ach 在啊组是比的增加的更多在一个组；ox-LDL 在的浆液水平啊， A 组比的低在一个组；痴呆度在 MDA，疼痛和 ox-LDL 的 atorvastatin treatment.ConclusionAtorvastatin 罐头减少浆液水平以后是更低的，并且特别，与血脂过多在广告增加草皮， Ach，和 attenuate 痴呆症状的。atorvastatin neuroprotection 的假设被结束那 atorvastatin 可以制止自由基反应并且延迟在广告的氧化。