肝癌患者血清P53抗体检测的临床意义

Clinical significance of serum P53 antibody in patients with hepatocellular carcinoma.

目的探讨血清p53抗体检测对肝癌的诊断价值。方法应用酶联免疫法(ELISA)检测46例肝癌患者血清p53抗体,对照组为30例健康体检者。结果(1)46例肝癌患者中18例血清p53抗体阳性,阳性率为39.1%,对照组均阴性,有显著性差异(P<0.01),(2)肝癌患者血清p53抗体阳性率与AFP水平,病理分化程度及肿瘤大小无相关关系(P>0.05)。结论血清p53抗体检测可以作为肝癌辅助诊断的指标。

Objective To explore the value of serum P53 antibody in patients with hepatocellular carcinoma. Methods Forty -six patients with hepatocellular carcinoma were tested for P53 by enzyme linked immunosorbont assay （ELISA） and 30 healthy individuals were recruited as control. Results Serum P53 antibody were detected in 39. 1% of patients, While all controls were negative （ P 〈 0. 01 ）. There were not difference among the positive rate of serum P53 antibody in patients and level of AFP, cell differentiation and size of cancer （ P 〉 0. 05 ）. Conclusion Detection of serum P53 antibody is helpful in diagnosis of hepatocellular carcinoma.