非活动性HBsAg携带者临床病理分析

Clinical pathology character analysis in non-active hepatitis B s antigen carriers

目的了解非活动性HBsAg携带者临床病理特点。方法对80例患者进行生化、病毒标志物及病毒定量检测,并和肝脏病理进行相关性分析。结果光镜下见肝组织基本正常者1例,病理诊断为慢性肝炎轻度者48例,中度以上者19例,占23.75%,活动性肝硬化者12例,占15%;抗HBe阴性组纤维化程度要重于抗HBe阳性组,其中大于S3的抗HBe阴性组患者占总数的60%,阳性组为26%,但肝脏炎症程度与抗HBe水平无关;血小板和胆碱酯酶对于代偿期肝硬化的诊断具有辅助价值。结论对于非活动性HBsAg携带者应尽可能进行肝脏病理检查以明确诊断,并指导治疗。

Objective To analyse clinical and pathology character of non - active hepatitis B s antigen carriers. Methods Biochemical indices, virus marker and viral load were mensurated in 80 cases non - active hepatitis B s antigen carriers. Correlation analysis was performed with pathological grading and staging. Results Only 1 cases liver tissues were basically normal under microscope, 48 cases mild damage, 10 cases moderate damage, 9 cases severe damage and 12 cases active liver cirrhosis was respectively diagnosed by pathology. However liver fibrosis staging in hepatitis B e antibody（HBeAb） - negative group were more advanced than that in HBeAb - postive group, the proportion above S3 was sixty percent in HBeAb - negative were more advanced than that in HBeAb - postive group, the proportion above S3 was sixty percent in HBeAb - negative group and twenty six percent in HBeAb - postive group, but inflammation grading has no correlation with HBeAb level. Platelet and cholinesterase have assistant value to diagnose compensated liver cirrhosis. Conclusion Liver biopsy and pathological examination should be carried out in non - active hepatitis B s antigen carries.