阿苯达唑和地塞米松对广州管圆线虫病疗效的动物试验

Research on the therapeutic effect of albendazole and dexamethasone against Angiostrongylus cantonensis

目的观察阿苯达唑和地塞米松治疗广州管圆线虫病的效果,探讨药物的作用机制。方法:以Balb/c小鼠为动物模型,在感染后不同时间,用不同剂量的阿苯达唑治疗,并设立地塞米松进行联合治疗对照组。小鼠于感染后第22d解剖,计数脑组织中存活虫体,以减虫数统计药物疗效;同时观察脑组织切片病理变化;应用透射电镜观察阿苯达唑对虫体超微结构的影响,对药物的作用机制进行探讨。结果阿苯达唑为治疗广州管圆线虫病的有效药物,感染早期用药效果显著。杀虫药和地塞米松的合用可有效减轻脑部炎症反应。阿苯达唑主要通过虫体体壁及肠道吸收而发挥作用。结论阿苯达唑和地塞米松的联合应用可以有效治疗广州管圆线虫病。

Angiostrongylus cantonensis is a zoonosis , now there have dispute against its cure though albendazole is a common used drug in clinical. This study evaluates the therapeutic effect through the worm recovery, histopathological of the mouse brain and observation the mechanism of action by transmission electron microscope. The results show that albendadole is an effective drug towards Angiostrongylus cantonensis. Time is an important factor even decide the therapaeutic effect. Only dexamethasone has no use towands the disease, Histopathological shows that co-therpy is an effect method to kill the worm and relieve the pathological changes of brain. Albendazole mainly act on the worm cortex and intestinal.